The Antibiotic Neomycin Enhances Coxsackievirus Plaque Formation

Regulation of the formation of alkaline phosphatase during neomycin biosynthesis.

The use of a washed-cell system to study the factors controlling the synthesis of alkaline phosphatase and neomycin by Streptomyces fradiae has shown that calcium and magnesium salts are stimulatory, with maximal synthesis of both achieved with a combination of these salts. Among all the carbon sources studied, only arabinose induces alkaline phosphatase synthesis, whereas glucose and other car...

Effect of the Antibiotic Neomycin on the Toxicity of the Glycoside Vicine in Rats

Vicine is hydrolyzed by microflora to highly reactive free radical generating compound divicine which causes mortality and other adverse effects. This study in the rats established the effect of a broad spectrum and poorly absorbed antibiotic, neomycin sulfate on the toxicity of vicine. The results showed extremely decrease in mortality rate in the group pretreated with neomycin. Hemoglobin (Hb...

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

Part of the inflammatory response in Alzheimer's disease (AD) is the upregulation of the inducible nitric oxide synthase (NOS2) resulting in increased NO production. NO contributes to cell signaling by inducing posttranslational protein modifications. Under pathological conditions there is a shift from the signal transducing actions to the formation of protein tyrosine nitration by secondary pr...

The Formation of Plaques by African Horse Sickness Viruses and Factors Affecting Plaque Size

Tracking the Dynamic Interactions during Plaque Formation